The Science Behind Xylitol-Based Products

Xlear Pro-Active Health Utilizes The Benefit Of Xylitol

Xlear Inc. centers on proactive health—staying healthy through transformational hygiene. Xlear and Spry xylitol-based products support that goal.

Learn the Benefits of Xylitol in Xlear and Spry Products.

As one of its chief tenets, Xlear, Inc. lives by Benjamin Franklin’s words, “An ounce of prevention is worth a pound of cure.” Through its transformational hygiene solutions with both Xlear and Spry brands, it provides effective ways for people to proactively take care of their health instead of merely addressing illness or problems when they come.

To achieve its goals, Xlear, Inc. relies on scientific research to provide innovation and new perspectives to not only create more effective paths towards health, but paths that are less expensive and more accessible.

Here is a list of studies for medical and dental professionals to study. They cover a host of areas around upper respiratory and oral health and provide a buttress for why xylitol and Xlear and Spry products should be recommended and used.

Medical and Dental Professionals, Click Here

Scientific Studies

Browse all of our studies or use the dropdown to filter studies by your area of interest.

Scientific Studies

Xylitol Nasal Spray for Acute Otitis Media in Children

Xylitol Nasal Spray for Prevention of Recurrent...

This study’s findings support the effectiveness and safety of xylitol nasal spray as a preventative measure against recurrent acute otitis media (AOM), in children between the ages of 1 and...

Xylitol Nasal Spray for Prevention of Recurrent...

2023

This study’s findings support the effectiveness and safety of xylitol nasal spray as a preventative measure against recurrent acute otitis media (AOM), in children between the ages of 1 and...

Sugar Alcohols Like Xylitol Deactivate Respiratory Viruses

Sugar Alcohols Like Xylitol Deactivate Respirat...

In this study, researchers wanted to ‘explore the antiviral potential of sugar alcohols against respiratory viruses with pandemic potential’ to help mitigate future pandemics. They found that "sugar alcohols [like...

Sugar Alcohols Like Xylitol Deactivate Respirat...

2023 Featured Video

In this study, researchers wanted to ‘explore the antiviral potential of sugar alcohols against respiratory viruses with pandemic potential’ to help mitigate future pandemics. They found that "sugar alcohols [like...

Tracking Virus Entry and Exit Points in Our Body

Tracking Virus Entry and Exit Points in Our Body

This article talks about a study from Stanford, which looks at how SARS-CoV-2 enters the tissue. Talking about the study, one of its authors said, "Our upper airways are the...

Tracking Virus Entry and Exit Points in Our Body

2023

This article talks about a study from Stanford, which looks at how SARS-CoV-2 enters the tissue. Talking about the study, one of its authors said, "Our upper airways are the...

Saline with Xylitol, SARS-CoV-2, and Anosmia

Saline with Xylitol, SARS-CoV-2, and Anosmia

In this study performed in the Dominican Republic, researchers ‘aimed to examine the efficacy of xylitol as an adjunct treatment for COVID-19 in an outpatient setting.’ They concluded that though...

Saline with Xylitol, SARS-CoV-2, and Anosmia

2022

In this study performed in the Dominican Republic, researchers ‘aimed to examine the efficacy of xylitol as an adjunct treatment for COVID-19 in an outpatient setting.’ They concluded that though...

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User Experience with a Gentle Spray Nozzle

Researchers wanted to see if using a nozzle that sprayed a gentler mist for nasal sprays would improve the user experience and thus compliance. They found that a specific nozzle,...

User Experience with a Gentle Spray Nozzle

2022

Researchers wanted to see if using a nozzle that sprayed a gentler mist for nasal sprays would improve the user experience and thus compliance. They found that a specific nozzle,...

Role of Natural Grapefruit Seed Extract Against SARS-CoV-2

Role of Natural Grapefruit Seed Extract Against...

Researchers wanted to study the effect grapefruit seed extract had on SARS-CoV-2 to see if it was a potential inhibitor of molecular docking. Using in silico method they found that,...

Role of Natural Grapefruit Seed Extract Against...

2021

Researchers wanted to study the effect grapefruit seed extract had on SARS-CoV-2 to see if it was a potential inhibitor of molecular docking. Using in silico method they found that,...

Can the Nasal Cavity Help Tackle COVID-19?

Can the Nasal Cavity Help Tackle COVID-19?

In this review, the authors set out to organize and summarize all the information now available for COVID-19 therapies, specifically those therapies which are administered through the nose. The article...

Can the Nasal Cavity Help Tackle COVID-19?

2021

In this review, the authors set out to organize and summarize all the information now available for COVID-19 therapies, specifically those therapies which are administered through the nose. The article...

Xylitol Blocks Viral Adhesion: Study on Human Airway Tissue

Xylitol Blocks Viral Adhesion: Study on Human A...

Researchers at Utah State University performed research to show that xylitol blocked viral adhesion on human airway tissue. Though a similar study was performed previously using industry standards (performed on...

Xylitol Blocks Viral Adhesion: Study on Human A...

2021

Researchers at Utah State University performed research to show that xylitol blocked viral adhesion on human airway tissue. Though a similar study was performed previously using industry standards (performed on...

Nasal Saline Irrigation Reduces Hospitalizations of COVID+ Outpatients

Nasal Saline Irrigation Reduces Hospitalization...

Researchers wanted to better understand if nasal irrigation would result in fewer hospitalizations after a positive COVID-19 test result. After conducting a study with 79 participants, researchers found that, "Patients...

Nasal Saline Irrigation Reduces Hospitalization...

2021

Researchers wanted to better understand if nasal irrigation would result in fewer hospitalizations after a positive COVID-19 test result. After conducting a study with 79 participants, researchers found that, "Patients...

Inhibition of Coronavirus 2 Replication

Inhibition of Coronavirus 2 Replication

In a study performed at the University of São Paulo, researchers found that a hypertonic saline solution inhibits the replication of SARS-CoV-2. They found that, ‘[The] data show that 1.2%...

Inhibition of Coronavirus 2 Replication

2021

In a study performed at the University of São Paulo, researchers found that a hypertonic saline solution inhibits the replication of SARS-CoV-2. They found that, ‘[The] data show that 1.2%...

Further Evidence of Xylitol’s Effectiveness Against Viruses

Further Evidence of Xylitol’s Effectiveness Aga...

In this study researchers used an electron microscope to take pictures of xylitol’s and grapefruit seed extract’s (GSE) interaction with the SARS-CoV-2 virus. They concluded, "Combination therapy with GSE and...

Further Evidence of Xylitol’s Effectiveness Aga...

2021

In this study researchers used an electron microscope to take pictures of xylitol’s and grapefruit seed extract’s (GSE) interaction with the SARS-CoV-2 virus. They concluded, "Combination therapy with GSE and...

Comprehensive Literature Review of Intranasal Therapy Against SARS-CoV-2

Comprehensive Literature Review of Intranasal T...

In this review, researchers looked at all the studies talking about intranasal therapy in fighting against SARS-CoV-2. They concluded, "Based on the literature review, it is encouraging to note that...

Comprehensive Literature Review of Intranasal T...

2021

In this review, researchers looked at all the studies talking about intranasal therapy in fighting against SARS-CoV-2. They concluded, "Based on the literature review, it is encouraging to note that...

Xylitol Reduces Preterm Births

Xylitol Reduces Preterm Births

In a study published in January of 2022, researchers wanted to see if using xylitol could reduce preterm birth. They conducted the study with 10,069 women in Malawi, the country...

Xylitol Reduces Preterm Births

2022

In a study published in January of 2022, researchers wanted to see if using xylitol could reduce preterm birth. They conducted the study with 10,069 women in Malawi, the country...

Xylitol and Dental Caries: A Systemic Review

Xylitol and Dental Caries: A Systemic Review

Researchers analyzed 16 studies looking at xylitol’s effect on dental caries, or cavities. In their review, the researchers found that, “Xylitol was found to be an effective strategy as self-applied...

Xylitol and Dental Caries: A Systemic Review

2017

Researchers analyzed 16 studies looking at xylitol’s effect on dental caries, or cavities. In their review, the researchers found that, “Xylitol was found to be an effective strategy as self-applied...

Improved Nasal Volume Using Saline Xylitol Mixture

Improved Nasal Volume Using Saline Xylitol Mixture

In this article Drs. Olmos and Baba discuss their findings which showed that 3 minutes after spraying participants’ noses with a saline and xylitol spray, they experienced a 20% improvement...

Improved Nasal Volume Using Saline Xylitol Mixture

2019

In this article Drs. Olmos and Baba discuss their findings which showed that 3 minutes after spraying participants’ noses with a saline and xylitol spray, they experienced a 20% improvement...

Influence of Maternal Xylitol Consumption

Influence of Maternal Xylitol Consumption

In a study looking into the impact of mothers using xylitol, researchers found that habitual xylitol consumption by mothers was associated with a statistically significant reduction of the probability of...

Influence of Maternal Xylitol Consumption

2000

In a study looking into the impact of mothers using xylitol, researchers found that habitual xylitol consumption by mothers was associated with a statistically significant reduction of the probability of...

Deactivation of SARS-CoV-2 with Xlear Nasal Spray

Deactivation of SARS-CoV-2 with Xlear Nasal Spray

In this paper, researchers look at two studies performed at Utah State University (2020) and University of Geneva (2020) which showed that Xlear Nasal Spray destroyed 99.99% of the SARS-CoV-2...

Deactivation of SARS-CoV-2 with Xlear Nasal Spray

2020

In this paper, researchers look at two studies performed at Utah State University (2020) and University of Geneva (2020) which showed that Xlear Nasal Spray destroyed 99.99% of the SARS-CoV-2...

Xylitol’s Method of Action against SARS-CoV-2

Xylitol’s Method of Action against SARS-CoV-2

Antony Cheudjeu found that xylitol blocks receptor cites of the SARS-CoV-2 virus which inhibits it from attaching to the cell wall of its host. Cheudjeu, A. (2020). Correlation of D-xylose...

Xylitol’s Method of Action against SARS-CoV-2

2020

Antony Cheudjeu found that xylitol blocks receptor cites of the SARS-CoV-2 virus which inhibits it from attaching to the cell wall of its host. Cheudjeu, A. (2020). Correlation of D-xylose...

Potential of Xylitol Plus Grapefruit Seed Extract Nasal Spray against SARS-CoV-2

Potential of Xylitol Plus Grapefruit Seed Extra...

In this case study, participants experienced a reduction of symptoms related to SARS-CoV-2 infection and received a negative test 50% faster than the average time of negativization. Go, C. C.,...

Potential of Xylitol Plus Grapefruit Seed Extra...

2020

In this case study, participants experienced a reduction of symptoms related to SARS-CoV-2 infection and received a negative test 50% faster than the average time of negativization. Go, C. C.,...

Nasal Irrigation Reduces Symptoms Related to SARS-CoV-2

Nasal Irrigation Reduces Symptoms Related to SA...

In this interim analysis, researchers evaluated the effect irrigating the nose and sinuses had on reducing symptoms related to SARS-CoV-2. They found, "The effect of nasal irrigation on symptom resolution...

Nasal Irrigation Reduces Symptoms Related to SA...

2020

In this interim analysis, researchers evaluated the effect irrigating the nose and sinuses had on reducing symptoms related to SARS-CoV-2. They found, "The effect of nasal irrigation on symptom resolution...

Using Nasal Sprays to Combat SARS-CoV-2

Using Nasal Sprays to Combat SARS-CoV-2

Researchers concluded that using a nasal spray that deactivates the SARS-CoV-2 virus in the nose, "may not only prevent person-to-person spread of SARS-CoV-2, but may also diminish the severity of...

Using Nasal Sprays to Combat SARS-CoV-2

2020

Researchers concluded that using a nasal spray that deactivates the SARS-CoV-2 virus in the nose, "may not only prevent person-to-person spread of SARS-CoV-2, but may also diminish the severity of...

Anti-Adherence of Viruses

Anti-Adherence of Viruses

In a study looking at lota-carrageenan's effect on SARS-COV-2, researchers found that xylitol also had an anti-adherence effect on the virus. Vega, J. C., et al., (2020). Iota carrageenan and...

Anti-Adherence of Viruses

2020

In a study looking at lota-carrageenan's effect on SARS-COV-2, researchers found that xylitol also had an anti-adherence effect on the virus. Vega, J. C., et al., (2020). Iota carrageenan and...

Benefits and Safety of Nasal Saline Irrigations in a Pandemic

Benefits and Safety of Nasal Saline Irrigations...

In this paper, researchers discuss how cleaning the sinuses with a simple saline could be useful during the pandemic. They conclude saying that adding anti-viral or virucidal agents to the...

Benefits and Safety of Nasal Saline Irrigations...

2020

In this paper, researchers discuss how cleaning the sinuses with a simple saline could be useful during the pandemic. They conclude saying that adding anti-viral or virucidal agents to the...

The Three Stages of SARS-CoV-2 Infection

The Three Stages of SARS-CoV-2 Infection

The paper’s authors show that like other illnesses which affect the lungs, the SARS-CoV-2 virus has three stages of infection, and if left unchecked, it could cause irreversible damage to...

The Three Stages of SARS-CoV-2 Infection

2020

The paper’s authors show that like other illnesses which affect the lungs, the SARS-CoV-2 virus has three stages of infection, and if left unchecked, it could cause irreversible damage to...

Mapping How SARS-CoV-2 Infects the Body

Mapping How SARS-CoV-2 Infects the Body

In this study done at UNC Chapel Hill, researchers found that the SARS-CoV-2 virus first infects the body through the nose, establishes itself there, and then progresses into the airway...

Mapping How SARS-CoV-2 Infects the Body

2020

In this study done at UNC Chapel Hill, researchers found that the SARS-CoV-2 virus first infects the body through the nose, establishes itself there, and then progresses into the airway...

High Viral Load in the Nose

High Viral Load in the Nose

In this correspondence, researchers shared their research which showed that the nose has the highest viral load of SARS-CoV-2 than elsewhere in the body when infected with the virus. Zou,...

High Viral Load in the Nose

2020

In this correspondence, researchers shared their research which showed that the nose has the highest viral load of SARS-CoV-2 than elsewhere in the body when infected with the virus. Zou,...

Using Xylitol for Rhinitis

Using Xylitol for Rhinitis

In 2019, researchers wanted to see the effectiveness of a xylitol solution in helping with rhinitis brought on by overuse of nasal decongestants. They concluded, "xylitol solution is effective as...

Using Xylitol for Rhinitis

2019

In 2019, researchers wanted to see the effectiveness of a xylitol solution in helping with rhinitis brought on by overuse of nasal decongestants. They concluded, "xylitol solution is effective as...

Xylitol and Nitric Oxide Creation in the Nose

Xylitol and Nitric Oxide Creation in the Nose

In this study, researchers wanted to look at the xylitol's efficacy in nasal hygiene for chronic rhinosinusitis while also understanding the effect xylitol had on nitric oxide. To measure the...

Xylitol and Nitric Oxide Creation in the Nose

2017

In this study, researchers wanted to look at the xylitol's efficacy in nasal hygiene for chronic rhinosinusitis while also understanding the effect xylitol had on nitric oxide. To measure the...

Airway Study

Airway Study

In a 2015 presentation, Dr. Nsouli shared his findings of a study which showed that a nasal spray with xylitol increased peak airflow 35% more than saline alone and measurably...

Airway Study

2015

In a 2015 presentation, Dr. Nsouli shared his findings of a study which showed that a nasal spray with xylitol increased peak airflow 35% more than saline alone and measurably...

Xylitol Nasal Irrigation in the Management of Chronic Rhinosinusitis

Xylitol Nasal Irrigation in the Management of C...

In this pilot study, researchers wanted to find out if irrigating the sinuses with a water-xylitol solution would improve symptoms of people suffering from chronic rhinosinusitis. They concluded, "Xylitol irrigations...

Xylitol Nasal Irrigation in the Management of C...

2011

In this pilot study, researchers wanted to find out if irrigating the sinuses with a water-xylitol solution would improve symptoms of people suffering from chronic rhinosinusitis. They concluded, "Xylitol irrigations...

Anti-Adherence of Bacteria

Anti-Adherence of Bacteria

This study found that xylitol blocked adhesion of bacteria to epithelial cells, showing that xylitol inhibits bacteria from sticking to tissue, which allows the body to wash them away. Kontiokari,...

Anti-Adherence of Bacteria

1998

This study found that xylitol blocked adhesion of bacteria to epithelial cells, showing that xylitol inhibits bacteria from sticking to tissue, which allows the body to wash them away. Kontiokari,...

Using Xylitol Nasal Spray to Reduce SARS-CoV-2 Infections

Using Xylitol Nasal Spray to Reduce SARS-CoV-2 ...

This study investigates the use of xylitol nasal spray on symptomatic and asymptomatic patients, who were high-risk healthcare workers at hospitals in India during the Delta variant phase of the...

Using Xylitol Nasal Spray to Reduce SARS-CoV-2 ...

2022

This study investigates the use of xylitol nasal spray on symptomatic and asymptomatic patients, who were high-risk healthcare workers at hospitals in India during the Delta variant phase of the...

Using Xylitol and Fluoride Together for Stronger, Healthier Teeth

Using Xylitol and Fluoride Together for Stronge...

Xylitol is known to help reduce cavity-causing bacteria. Additionally, researchers have found that xylitol products support fluoride’s remineralization and strengthening efforts. In one study, they even found that xylitol helps...

Using Xylitol and Fluoride Together for Stronge...

2021

Xylitol is known to help reduce cavity-causing bacteria. Additionally, researchers have found that xylitol products support fluoride’s remineralization and strengthening efforts. In one study, they even found that xylitol helps...

Xylitol and Erythritol Inhibition of Bacterial Growth and Biofilm Production

Xylitol and Erythritol Inhibition of Bacterial ...

Researchers wanted to look how the polyols xylitol and erythritol work together to inhibit the growth of oral bacteria S. Mutans and Sobrinus. They concluded, “Our results demonstrate significant polyol...

Xylitol and Erythritol Inhibition of Bacterial ...

2020

Researchers wanted to look how the polyols xylitol and erythritol work together to inhibit the growth of oral bacteria S. Mutans and Sobrinus. They concluded, “Our results demonstrate significant polyol...

Xylitol and Erythritol Working Together to Improve Oral Health

Xylitol and Erythritol Working Together to Impr...

Researchers wanted to see how xylitol and erythritol affected oral health both individually and synergistically. They concluded, “Both erythritol and xylitol as well as their combinations inhibit the growth of...

Xylitol and Erythritol Working Together to Impr...

2020

Researchers wanted to see how xylitol and erythritol affected oral health both individually and synergistically. They concluded, “Both erythritol and xylitol as well as their combinations inhibit the growth of...

Effect of Xylitol on Various Oral bacteria

Effect of Xylitol on Various Oral bacteria

In a study done at Pusan University in Korea back in 2013, researchers investigated xylitol’s effect on a range of oral bacteria. Hundreds of studies have focused on the bacteria...

Effect of Xylitol on Various Oral bacteria

2013

In a study done at Pusan University in Korea back in 2013, researchers investigated xylitol’s effect on a range of oral bacteria. Hundreds of studies have focused on the bacteria...

High-dose Xylitol in High-risk Caries Subjects

High-dose Xylitol in High-risk Caries Subjects

“The hypothesis was that the daily use of a high dose of a xylitol chewing gum for 6 months would reduce the increment of decayed permanent first molar surfaces in high-risk...

High-dose Xylitol in High-risk Caries Subjects

2013

“The hypothesis was that the daily use of a high dose of a xylitol chewing gum for 6 months would reduce the increment of decayed permanent first molar surfaces in high-risk...

Xylitol’s Effect on Good Oral Bacteria

Xylitol’s Effect on Good Oral Bacteria

Researchers wanted to better understand xylitol’s effect on good oral bacteria, whether it affects these bacteria like it does S. mutans. They found, “Based on the findings of this study,...

Xylitol’s Effect on Good Oral Bacteria

2012

Researchers wanted to better understand xylitol’s effect on good oral bacteria, whether it affects these bacteria like it does S. mutans. They found, “Based on the findings of this study,...

Xylitol and Oral Streptococci Adherence

Xylitol and Oral Streptococci Adherence

Research has shown that “Xylitol consumption decreases counts of mutans streptococci.” However, the method of action isn’t understood as well. Researchers wanted to better understand the mechanism behind xylitol’s ability....

Xylitol and Oral Streptococci Adherence

2010

Research has shown that “Xylitol consumption decreases counts of mutans streptococci.” However, the method of action isn’t understood as well. Researchers wanted to better understand the mechanism behind xylitol’s ability....

Xylitol Chewing Gum and Caries Rates

Xylitol Chewing Gum and Caries Rates

Dental caries is a pandemic infectious disease which can affect quality of life and consume considerable health care resources. The study found that the four xylitol gums were most effective...

Xylitol Chewing Gum and Caries Rates

1995

Dental caries is a pandemic infectious disease which can affect quality of life and consume considerable health care resources. The study found that the four xylitol gums were most effective...

Xylitol and Remineralization of Teeth: A Literature Review

Xylitol and Remineralization of Teeth: A Litera...

K.K. Makinen, one the of pioneers of xylitol research, wanted to see how xylitol and other polyols affect oral health by remineralizing teeth. It is well-known that shallow decay can...

Xylitol and Remineralization of Teeth: A Litera...

2010

K.K. Makinen, one the of pioneers of xylitol research, wanted to see how xylitol and other polyols affect oral health by remineralizing teeth. It is well-known that shallow decay can...

Xylitol and the Break Down of Oral Biofilm

Xylitol and the Break Down of Oral Biofilm

Biofilm is a bacterial colony where bacteria can thrive and flourish. Researchers wanted to see how to break down these harmful biofilms. In this study they found, “Xylitol has a...

Xylitol and the Break Down of Oral Biofilm

2008

Biofilm is a bacterial colony where bacteria can thrive and flourish. Researchers wanted to see how to break down these harmful biofilms. In this study they found, “Xylitol has a...

Non-Cariogenic Sweeteners and Dental Caries

Non-Cariogenic Sweeteners and Dental Caries

“The purpose of this report is to review the current published evidence regarding the relationship between sugar substitutes and dental caries…These studies demonstrated a consistent decrease in dental caries, ranging...

Non-Cariogenic Sweeteners and Dental Caries

2001

“The purpose of this report is to review the current published evidence regarding the relationship between sugar substitutes and dental caries…These studies demonstrated a consistent decrease in dental caries, ranging...

Turku Sugar Studies

Turku Sugar Studies

The purpose was to study differences in the caries increment rate as influenced by various sugars…The results showed a massive reduction of the caries increment in relation to xylitol consumption.”...

Turku Sugar Studies

1976

The purpose was to study differences in the caries increment rate as influenced by various sugars…The results showed a massive reduction of the caries increment in relation to xylitol consumption.”...

Sorbitol’s Interaction with Cavity-Causing Bacteria

Sorbitol’s Interaction with Cavity-Causing Bact...

Most dental care companies make toothpaste and oral care products using sorbitol. However, studies show that sorbitol feeds the bacteria that cause cavities. Researchers have found that Strep. mutans metabolizes,...

Sorbitol’s Interaction with Cavity-Causing Bact...

1973

Most dental care companies make toothpaste and oral care products using sorbitol. However, studies show that sorbitol feeds the bacteria that cause cavities. Researchers have found that Strep. mutans metabolizes,...

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